urinary tumor necrosis factor-alpha a good indicator for inflammatory response in pyelonephritis

background tnf-α is one of the most potent cytokines in proinflammatory reactions. results one hundred and twenty children with acute pyelonephritis were evaluated. urinary tnf-α/cr was 0.0051 ± 0.00083 pg/g creatinine. the authors found out a significant difference in urinary tnf-α/cr between patients who have normal and abnormal levels of urine leukocytes, urine protein, urine culture, erythrocyte sedimentation rate and c- reactive protein. this study revealed a significant correlation between urinary tnf-alpha and urine wbc (r = 0.36, p value = 0.02), esr (r = 0.75, p value = 0.03) and crp (r = 0.58, p value = 0.02). patients and methods this cross sectional study, was performed on children with acute pyelonephritis. fresh random urine samples were obtained before treatment of pyelonephritis. urine samples were tested for tnf-α and creatinine. we also evaluated our patients with routine biochemical studies. objectives this article contributes to evaluate the correlation between urinary tnf-α and inflammatory response markers in children with acute pyelonephritis. conclusions we concluded that urinary tnf-α/cr might be a good indicator for inflammatory response in children with acute pyelonephritis.